Kaleido Scope4y
UAB Guidelines for Conducting Human Xenograft Experiments in Mice
For human xenograft experiments in mice and administration of primary human material not suspected of harboring a human pathogen, standard ARP handling practices for housing and cage changing can be ...
Triple combination of inhibitors emerges as potential new treatment for aggressive cancer
A multicenter collaboration has identified a potential new treatment for an aggressive sarcoma arising in the nerves. The ...
BioWorld1mon
Researchers develop humanized xenograft glioblastoma model in mice
Researchers have described the development of a novel murine model of glioblastoma established with a patient-derived xenograft (PDX) in humanized mice that harbored an almost complete human immune ...
Dewpoint Therapeutics Announces DPTX3496 as a Development Candidate for the Treatment of Colorectal, Breast, and Lung Cancers
Dewpoint Therapeutics’ second development candidate, DPTX3496 is an oral, small molecule acting via a novel ...
Silexion Therapeutics Reports Strong Tumor Growth Reduction from Systemic Administration of SIL-204 in Preclinical Pancreatic Cancer Models
New preclinical findings provide validation for Silexion’s new systemic administration approach for SIL-204, demonstrating ...
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma
This was further validated in an HCC xenograft mouse model, where the combination of shCD39-CAR-T cells with mdivi-1 resulted ...
Silexion Therapeutics reports preclinical data for SIL-204
Silexion Therapeutics (SLXN) announced new preclinical data for SIL-204, its next-generation siRNA therapeutic candidate. The findings ...
Baylor College of Medicine4y
Patient-Derived Xenograft Core
The primary focus Patient-Derived Xenograft (PDX) Core is to develop, and provide to the Baylor PDX community, computational and bioinformatics infrastructure to support large scale generation, ...