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清华伉俪揭示红斑狼疮新机制，可用于开发自身免疫疾病靶向药物总结来说，本次研究揭示了 YTHDF1 和 m6A 修饰在抗体稳态维持和免疫调控中的关键作用。也揭示了在系统性红斑狼疮患者中，YTHDF1 的过表达可能与 ...
The m6A binding protein YTHDF1 is frequently upregulated in cancer. Here the authors report that USP5 deubiquitinates and stabilizes YTHDF1, associated with cancer growth and immune evasion ...
m6A结合蛋白YTHDF1在癌症中经常上调。在这里，作者报告了USP5去泛素化并稳定与癌症生长和免疫逃避相关的YTHDF1，并且在临床前模型中靶向USP5增强了对抗pd - l1的反应。 靶向 USP5 增强癌症免疫治疗 ...
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