Conversion of the 5′-triphosphate to a monophosphate now appears to be the first committed step in mRNA decay in E. coli. Figure 1: E. coli mRNA decay is activated by the conversion of the mRNA ...

RNA abundance is regulated by balancing transcription and degradation in processes that control the temporal and spatial distribution of cellular RNA. In eukaryotic cells, mRNA decay is catalyzed by ...