Messenger RNA abundance is determined by balancing transcription and RNA decay. mRNA stability can be rapidly ... lives spanning several cell cycles 1. Moreover, although the decay rates of ...

In eukaryotic cells, mRNA decay is catalyzed by two major pathways, and both can be initiated by deadenylation of the polyadenylated (poly-A) tail. After decapping, 5’ to 3’ RNA degradation is ...