Although the mTOR pathway has been characterized in T cells, it has not been well described in other immune cells. In this study, Weichhart et al. investigated how mTOR activity in phagocytes ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple aspects of cell growth and homeostasis. Our work on genomic integrity ranges from the Fanconi ...

A new priority review was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) on January 12, 2025, entitled “Mikhail ‘Misha’ Blagosklonny’s enduring ...

Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting ...

Their findings pointed to dysregulation in the mTOR (mammalian target of rapamycin) pathway in both types of lissencephaly organoids they were studying. "This is a fundamental pathway that governs ...

The research team also performed several analyses to evaluate the gene and protein expression levels in the organoids. Their findings pointed to dysregulation in the mTOR (mammalian target of ...