They identified the mechanistic target of rapamycin complex 1 (mTORC1) pathway as a highly used system. Then the researchers developed a conditional mutant mouse model with a deleted upstream mTORC1 ...

However, long-term use may impair mTORC2 assembly and functioning. [9] Although less is known about this complex than mTORC1, two major functions have been attributed to mTORC2: regulation and ...