作为曾经红极一时的研究方向，想必 miRNA 的大名早已在各位的脑海中留下过或深或浅的印象。这位 在中心法则之外影响着基因表达的“幕后黑手” 在教科书上虽然占有的篇幅不长，却在生命活动中举足轻重；同样的，它也是个十分重要的考点。在今日， 2024 ...

In attempts to classify various forms of cancer with microarray expression profiles, miRNAs have been shown to harbor more information about disease states than do mRNA profiles (133). MicroRNA ...

The RISC, guided by the miRNA, binds to complementary sequences in the 3' untranslated region (UTR) of target messenger RNAs (mRNAs). This binding leads to translational repression or mRNA degradation ...

There are notable differences between men and women in their susceptibility to many human diseases, including cardiovascular ...

"MicroRNA is quite stable ... The recipes from DNA are carried by messengers called messenger RNA or simply mRNA. Does this sound familiar? Several of the COVID-19 vaccines used in Norway are ...

microRNA作为非编码RNA的一种，通过调控mRNA分子来影响基因表达，进而参与几乎所有生命活动的调控。尽管其重要性日益凸显，但microRNA药物研发尚属 ...

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by memory and physical impairment in aged individuals. microRNAs (miRNAs) are small, single-stranded noncoding ...

1 This means miRNA guides can target any mRNA with homology to its seed region, even if the rest of the sequence is not a match. This promiscuous binding activity means that miRNA can act on many ...

Victor Ambros and Gary Ruvkun won this year’s Physiology or Medicine award for the discovery of microRNA and its role in post-transcriptional gene regulation. Danielle is an Assistant Editor at The ...

The origin of their recognition comes from a pair of studies published in the journal Cell way back in 1993, which demonstrated for the first time that microRNA ... of mRNA-based COVID-19 vaccines.