Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

These platforms enable the generation of new, more relevant therapeutics against fibrosis and solid tumors, and meaningful biomarkers to ensure their delivery to the right patients. The ECM ...

Lipid peroxidation products are emerging as important stimuli to ECM production ... efforts to use antioxidants as therapy for hepatic fibrosis (see section on Therapy of Hepatic Fibrosis ...

leading to ECM fibrosis. Simultaneously, the stiff ECM activates the YAP pathway in CAFs through integrins, exacerbating this process. Based on the role of metabolism in tumor progression ...

Importantly, fibrosis is not a static process; it is reversible under certain conditions, as inflammatory responses subside ...

Syn-Coll, a synthetic tripeptide derived from the collagen sequence, has garnered attention in scientific research for its hypothesized potential to influence processes associated with extracellular ...