Conversely, might a factor produced by the db/db mutant mouse cause ... acids or lipid extracts of adipose tissue. In humans, many leptin deficiency syndromes are responsive to leptin replacement ...

Although regulation of leptin synthesis and release is poorly understood, a distinct circadian pattern for plasma leptin concentrations has been observed and is similar to that of prolactin and ...

Using a mouse model of the disease, May-yun Wang et al. 1 tested the effects of treating diabetes with another hormone, leptin. Leptin is secreted by fat cells and is known for modulating energy ...