The intestine maintains a delicate balance in the body, absorbing nutrients and water while maintaining a healthy relationship with the gut microbiome, but this equilibrium is disrupted in parts ...

Because sex and pregnancy hormones regulate RANK–RANKL signalling, we assessed the structure ... exposed mouse and human intestinal organoids (self-organized 3D tissues derived from intestine ...

When rotated, a hole formed in their center, resulting in a tubelike structure. Upon transplanting the organoid into mice, it reportedly grew to the same size as a mouse's small intestine.

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation—and relocation—as they fight infections in the small intestine.