This is especially important because the RNAi machinery (the RISC complex in particular) is saturable, at least in some settings. Again, the rescue control outlined below is especially important ...

So it makes sense that researchers are now trying to harness the cell's RNAi machinery to fight a wide range of viruses. One of the most noteworthy is hepatitis C, which infects roughly 200 ...

Results reported in a recent Science paper provide the first experimental evidence to support the hypothesis that prokaryotes possess a defence system that might be analogous to eukaryotic RNA ...

the cytoplasm where the RNAi ‘machinery’ resides. Alnylam says its early-stage trials have shown its delivery method can ‘knock down’ the target gene with 99% efficacy without causing any ...

I want to emphasize that they work upstream of standard medicines, which generally target proteins. RNAi therapeutics target and destroy mRNA the step before a protein is made. Also, we’re taking ...

Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of ...

After translation of the viral proteins that are necessary to establish the viral-replication machinery, viral RNA replication begins (Figure 1). Similar to other positive-strand RNA viruses ...

Ribosomal RNA (rRNA) is a component of the ribosomes, the cellular machinery responsible for protein synthesis. rRNA molecules, along with ribosomal proteins, form the structure of the ribosomes and ...