activating nearby antigen presenting cells (APCs), notably dendritic cells (DCs), and repolarizing tumor-associated macrophages (TAMs) toward an M1 phenotype. In addition to direct phagocytosis of ...

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk ...

and tumor-associated macrophages as well as uncovering crucial adaptive T cell regulation pathways in cancer. Using murine genetic cancer models and patient tumor specimens, we were the first to ...

In the new study, which focused on breast cancer, the authors report that tumor-associated macrophages (TAMs), a type of immune cell found abundantly in the tumor microenvironment, respond to the ...

The LifeTracDx tests were made possible by Creatv’s discovery of cancer-associated macrophages in cancer patient blood and their clinical applications. These macrophages are scavenger cells that ...

How would you summarize your study for a lay audience?Ependymoma (EPN) is a common form of brain cancer in children, with few ...

Discover how immune iFRET biomarkers offer new insights into predicting response to neoadjuvant melanoma therapy, driving advances in precision immunotherapy.

Rakesh Jain Ph.D., Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior ...

The study introduces an innovative tracer targeting CD163, a molecular receptor on tumor-associated macrophages—immune cells that support tumor growth and protection. The tracer is based on ...

The Arkansas Integrative Metabolic Research Center will host Jeffrey Rathmell, a professor of pathology, microbiology and immunology from Vanderbilt University on Wednesday, Jan. 22.

Cancer-associated fibroblasts (CAFs), distinguished ... the interactions between CAFs and innate immune cells (such as macrophages, neutrophils, mast cells, etc.) as well as adaptive immune ...