The kappa opioid receptor (KOR) and the endogenous peptide-ligand dynorphin have received significant attention due the involvement in mediating a variety of behavioral and neurophysiological ...

One significant area of research has been the investigation of opioid receptors in birds. A study on budgerigars revealed that κ-opioid receptors are more abundant than µ-opioid receptors in ...

2023), which works by binding to mu opioid receptors (known as MORs) in the brain and abruptly disrupting their signaling. However, those treated with naloxone often report that being rescued from an ...

A118G (43AA, 19AG, 18GG) 80 Taiwan females following abdominal hysterectomy GG had significantly higher postoperative day 1 morphine requirements [104] A118G Caucasians: 66 = AA, 29AG; Africans: 1 ...

δ-opioid receptors; KOR, κ-opioid receptors; GABAAR, GABAA receptors; GABABR, GABAB receptors; mGluR, Metabotropic glutamate receptors; NMDAR, N-methyl D-aspartic acid receptors; AMPAR, ...

linaclotide), μ-opioid receptor (OR) and κ-OR agonist, δ-OR antagonist (eluxadoline), histamine H1 receptor antagonist (ebastine), neurokinin-2 receptor antagonist (ibodutant) and GABAergic agents ...

Having shown last week that its opioid alternative can reduce post-surgery pain, Tris Pharma is back with another slice of clinical data to show that the drug is less likely to be abused.

Anorexia nervosa (AN) is a severe psychiatric disorder, characterized by restricted eating, fear to gain weight, and a distorted body image. Mu-opioid receptor (MOR) functions as a part of complex ...

Prescription opioids are primarily used for pain relief. They do so by getting attached to opioid receptors in the brain cells to release signals that block the perception of pain, and boost the ...

The company tested cebranopadol, a dual nociceptin/orphanin FQ peptide (NOP) receptor and µ-opioid peptide (MOP) receptor agonist, in a late-stage trial on patients who have undergone cosmetic ...

all work by activating nerve cells called opioid receptors that, in turn, then block pain signals from the body to the brain. Morphine, codeine, oxycodone, hydrocodone and fentanyl are all opioids.