Cell cycle re-entry of senescent breast cancer cells after CDK4/6 inhibition (CDK4/6i) constitutes a major source of disease ...

A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known as natural products. Natural products have been a prolific source and an inspiration for numerous ...

Targeting colibactin production may be a strategy to restrain the production of pro-tumourigenic factors. HCT116, Int-407 and IEC-6 harbour a wild-type (WT) p53 gene, whereas HCT8, Caco2 and HT-29 ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

Furthermore, the Le a epitope, which is a rare terminal modification of Physcomitrella N-glycans, was abolished in this organism by the single knock-out of the gene encoding the responsible β1,3 ...

Correspondence to Dr Mark R Fox, Laboratory and Clinic for Disorders of Gastrointestinal Motility and Function, Center for Integrative Gastroenterology, Klinik Arlesheim, Arlesheim 4144, Switzerland; ...

Feb. 6, 2025 — Despite new medication, cystic fibrosis often leads to permanent lung damage. Researchers have discovered that the disease causes changes in the immune system early in life ...