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15 小时
Cell | 单胚胎蛋白质组学突破——助力不孕不育诊断与个性化治疗
引言我们生命的起点,始于精子与卵子结合形成受精卵(zygote),随后在短短几天内经历一系列精密调控的分裂与分化,最终发展成具有多种细胞类型的囊胚(blastocyst),为胚胎成功植入子宫做好准备。然而,即便在最理想的生殖条件下,仍有大量受精卵无法 ...
8 天
类胚胎模型研究取得重要突破
研究团队通过优化诱导体系,在形态学和转录组水平上成功建立了与人类正常囊胚相似的类囊胚(4CL-blastoid),首次对不同培养体系下的人多能干细胞及其生成的blastoid的DNA甲基化和基因印记模式进行分析,并与人类正常囊胚进行对比。
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