PAM is associated with significant side effects and often with tachyphylaxis ... can be repeated once 1 h later Almotriptan – Axert® 6.25, 12.5 mg tablets 12.5 mg p.o.; can be repeated once ...

Patients should be reassured that these effects are usually self-limited ... Patients were switched if they were stable on a minimum dose of 25 mg b.i.d. carvedilol or 100 mg metoprolol.

These experiments not only confirmed the previous results in HepaRG cells and primary human hepatocytes, but also showed that CYPs other than CYP2D6 contribute to O-demethylation of metoprolol, the ...