The new study adds to growing evidence that measuring activated proteins is key to cancer therapy selection.Golden, CO, Feb. 10, 2025 (GLOBE ...

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes promote clonal selection and cancer hallmark behaviours that act to elevate ...

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Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including ...

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Mutations in PIK3CA, AKT1, and alterations in PTEN occur frequently ... which followed earlier failures in TNBC. Vertex's gene-editing therapy for sickle cell disease, Casgevy, has been given ...

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In various cellular models, including iPSC-derived neural cells, immune cells and fibroblasts, PD-associated mutant LRRK2 G2019S increases mtDNA damage that is abrogated by either gene editing to ...