Acute pancreatitis (AP) is a gastrointestinal disorder characterized by inflammation and necrosis of the pancreatic acinar cells. Mitochondrial homeostasis is key to energy metabolism and redox ...

FIP is defined by the presence of one or more of the following features: (1) inter-lobular fat, which is the presence of cells containing fat between pancreatic lobules; (2) lipid droplets within ...

Hans Clevers 研究团队利用类器官技术解锁胰腺再生新篇章！刊发在《Cell》（IF：45.5）的最新研究论文[1]显示，科学家通过类器官和单细胞基因测序等技术，发现人类胎儿胰腺中的LGR5+干细胞群，并开发了一种能够在体外长期扩增并具备分化潜力的类器官系统，首次实现了人类胰腺三种主要细胞类型的体外生成。该研究为揭示胰腺疾病发育机制，开发治疗胰腺炎、糖尿病等胰腺相关疾病新药提供了新策略。

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

Bone-marrow-derived multipotent progenitor stromal cells — or mesenchymal stem cells (MSCs) — are the common predecessors of cells of the mesenchymal lineage, such as bone, cartilage and fat ...

Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

In this section we describe how MYC plays a key role in multiple aspects of the biology of cells and tissues. This is also summarised in Figure 1. FIGURE 1. A “Hallmarks” style representation of MYC’s ...

Pluripotent stem cells are cells that have the capacity to self-renew by dividing and to develop into the three primary germ cell layers of the early embryo and therefore into all cells of the ...

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This delicate procedure requires technical skill for the preparation of AM with attached corneal epithelial cells and surgical dexterity to manipulate the AM onto the ocular surface. As previously ...

This had never happened before. There is a remarkable story behind these cells; it's more than half a century old, but still relevant and current. Dr Maninder Ahluwalia, senior lecturer in ...