HER2-positive breast cancer accounts for 20–30% of all breast cancers and has the second-poorest prognosis among breast cancer subtypes. The approval of trastuzumab in 1998 has significantly improved ...
a conditionally activated T-cell-engaging bispecific antibody targeting the epidermal growth factor receptor (EGFR) on tumour cells and the CD3 receptor on T-cells, developed in partnership with ...
The results above have elucidated how GP73 is activated in cancer cells; furthermore ... Further pieces of evidence prove that, as well as GP73/EGFR interaction, MMP-2 and MMP-7 interact with the ...
and the immediate implications for clinical practice and research Resistance to anti-EGFR therapy is a clinical issue for patients with advanced head and neck cancers. Here, the authors show that ...