Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme, which converts GTP to the second messenger cGMP in response to signalling from gaseous ligands, particularly nitric oxide (NO).

Cataclysm:Dark Days Ahead and the Ultimate Cataclysm tileset is the result of contributions from volunteers under the Creative Commons Attribution ShareAlike 3.0 license. The code and content of the ...

1 Department of Immunology, Harvard Medical School, Boston, MA, United States 2 The Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard, ...

Sustained exposure to pathological stress stimulates the heart to hypertrophy, increasing disease and mortality risk. New therapies to blunt this process include targeting enzymes below the cell ...

Background: Osteocalcin has attracted attention for its potential role in diabetes management. However, there has been no bibliometric assessment of scientific progress in this field. Methods: We ...

Activation of MAP kinase enzymes themselves is unusual in that they require phosphorylation on both a threonine (Thr) and tyrosine (Tyr) residue and thus need the activity of dual specificity kinases ...

We also used agonists and antagonists of the MAPK and NF-κB pathways to investigate the possible pathway involved. Peripheral blood mononuclear cells from one healthy donor were also used for ...