Nephrotoxicity, the major complication of long-term therapy with amphotericin B, is attributed to drug-induced renal vasoconstriction plus a direct toxic action on renal tubules. Hypokalemia and ...

Researchers have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and the evolution of catalytically active RNA. Researchers ...

which has thus become one of the most important means we have for investigating molecular structure. There is, indeed, no experimental method that gives more detailed information on this subject.

Molecular tests can improve the diagnosis of fungal infections. Despite the increasing application for fungal detection, molecular tests are still not accepted as a diagnostic criterion to define ...

This study investigates the potential clinical synergy between the PARP inhibitor niraparib (Zejula) and concomitant statins, exploring their combined effects on progression-free survival (PFS) in ...

The results of this theoretical approach indicated that all benzodiazepines derivatives fully comply with the Rule of Five. That is, Lipinski’s parameters describe that these compounds possess ...

He graduated in 1964 from the University of Edinburgh with a degree in chemistry, which led to a research position studying the molecular structure of natural gums in specimens of acacia plants ...

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. 4School of Pharmaceutical Sciences and ...

These shifts highlight specific molecular mechanisms ... such as immune signaling and neuronal structure maintenance. These analyses uncovered significant losses in neurogenic potential and ...

School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan 523808, P. R. China Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key ...

Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China ...