All these effects are mediated by the interactions of opioids with members of the opioid receptor family. Opioid binding sites were first discovered in mammalian brain (Pert and Snyder 1973 ...

Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and ...

They showed that an experimental opioid, which binds to an unconventional spot in the receptor, suppresses pain in animal models with fewer side effects—most notably those linked to fatal overdoses.