New research published in the Journal of Chromatography A examines the effect of flow rate on plate height and resolution for antisense oligonucleotides (ONs) under hydrophilic interaction liquid ...

In this study, we tested if locked nucleic acid (LNA) miR-181a-5p antisense oligonucleotides (ASO) could be used as a therapeutic to limit articular cartilage degeneration. Methods We used a variety ...

State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center and School of Pharmaceutical Sciences, Peking University, No. 38, Xueyuan Rd, Beijing 100191, China ...

Jan. 31, 2025 — Researchers compared the environmental impacts of lithium-ion battery recycling to mining for new materials and found that recycling significantly outperforms mining in terms of ...

By blocking the FcRn, the first thing you do is you prevent the FcRn receptor from recycling IgG [immunoglobulin G], and therefore IgG reduces out of circulation. IgG includes pathogenic IgG and ...

1,2 About 10% of patients are triple seronegative (ie, negative for antibodies to AChR, MuSK, and LRP4). The availability of different FcRn inhibitors and different application schemes will allow for ...

A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare ...

It is early morning, and 31-year-old Daniel Silberstein collects his bike from the storeroom in his block of flats. But not before he has separated out his empty ...

Immunovant’s IMVT-1402 is highlighted as the most convenient FcRn inhibitor in late-stage development, featuring an easy-to-use subcutaneous auto-injector. The drug’s potential for deeper IgG ...

“Circularity” in this sense refers to waste-management principles calling for the end of life of a product to be designed for the object’s reuse or recycling. The first step is to design ...