Axonal degeneration and neuroinflammation are critical processes involved in various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Recent research has ...

To test this, we utilized mice deficient in Sarm1 (Sarm1-/-), a molecular trigger of axon degeneration and the loss of which leads to axonal protection after injury. Methods: Wildtype and Sarm1-/-male ...

The Massachusetts based biotech will now press ahead with human trials for its antisense oligonucleotide (ASO) therapy, ...

Conclusions Taken together, these studies suggest that persistent Na + conductances are upregulated in FALS and that this upregulation is intrinsically associated with axonal degeneration.

Axonotmesis indicates a loss of axon continuity, though the endoneural tube is preserved. This structural injury results in wallerian degeneration. Severe crush or traction injuries can produce ...

Amylyx Pharmaceuticals Announces FDA Has Lifted the Clinical Hold on AMX0114 Phase 1 Clinical Trial for the Treatment of ALS ...

CONCLUSIONS In GBS with antiganglioside antibodies, isolated absence of F waves is a frequent conduction abnormality especially in the early phase of the disease, and may be caused by axonal ...

In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...

Delve into the increasingly dynamic landscape of ALS treatment development with thirteen companies advancing candidates in ...

Amylyx will be allowed to run a Phase I trial after the FDA lifted a clinical hold of its investigational ALS drug.