Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

An insufficient amount of beta cells or defects in the molecular mechanisms leading to glucose-induced insulin secretion trigger the development of diabetes, a severe disease with epidemic spreading ...

Researchers at IISc Bengaluru discover potential drug-free treatment for diabetes by enhancing beta-cell function with small ...

For several years, Lena Eliasson's research group has explored mechanisms that regulate insulin secretion from beta cells situated in the islets of Langerhans within the pancreas. Together with ...

Increased insulin secretion The protein IGFBP7 is regulated by a gene with the same name. When this gene was knocked out in beta cells from people with type 2 diabetes, the researchers found an ...

Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

First and second phase insulin secretion was assessed using the Stumvoll equation ... Tacrolimus is primarily associated with development of PTDM through its calcineurin inhibitor effect in beta cells ...

a biomarker indicating that transplanted beta cells are producing insulin. C-peptide levels also increase with a mixed meal tolerance test (MMTT), consistent with insulin secretion in response to ...

Background The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...