The endocrine cells confined in the islets of Langerhans are responsible for the maintenance of blood glucose homeostasis. In particular, beta cells produce and secrete insulin, an essential hormone ...

Research in cell biology uses microscopic and molecular tools and examines all cell types, from unicellular organisms such as protozoa to the specialised cells that consitutute multicellular ...

Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

A substantial number of studies using genetically engineered mouse models have demonstrated an essential role of FGF10 in the development of many organs and tissues including the pancreas. During ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Wu et al. report that MED16, a novel component of the MYC2–MED25 functional complex in Arabidopsis, stabilizes MED25 by competing with MED25-BINDING RING-H2 PROTEIN1 (MBR1) and MBR2 for binding ...

Objective Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions ... which ...

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...

Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma (PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate ... Our work provides a comprehensive ...

This had never happened before. There is a remarkable story behind these cells; it's more than half a century old, but still relevant and current. Dr Maninder Ahluwalia, senior lecturer in ...