AI-designed esmGFP protein could not have evolved naturally Scientists say esmGFP took 500M years’ worth of mutations to design AI-driven protein engineering could advance medicine and drug discovery ...

Guided by a multimodal generative language model called ESM3, Thomas Hayes and colleagues generated and synthesized a previously unknown bright fluorescent protein, with a genetic sequence so ...

Unlike fluorescent proteins, bioluminescent proteins do not require external light for excitation, avoiding issues like phototoxicity and background light. However, their use has been limited by ...

“ESM3 understands all this biological data, translates it, and speaks it fluently to use as a generative tool.” Rives and his collaborators applied ESM3 to the task of creating a new green fluorescent ...

This Review focuses on the uses of autofluorescent proteins (AFPs) and fluorescence techniques such as Förster resonance energy transfer (FRET) by microbiologists. Flow cytometry, which is a ...

A NOVEL method for the fluorescent labelling of proteins has been described recently which involved treatment of a protein solution with an active labelling dye dispersed, on diatomaceous earth or ...

Academy of Scientific and Innovative Research (AcSIR), Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201002, India ...

A research team from the Department of Chemistry at UNIST has announced that they have identified a novel pathway through which blue light can damage cellular proteins. Blue light, which emanates ...

Single-cell protein analysis has emerged as a powerful tool for understanding cellular heterogeneity and deciphering the complex mechanisms governing cellular function and fate. This review provides a ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

(C) The workflow for visualizing subcellular protein enrichment by localization index (LI ... For rGFP imaging, fixed brains were mounted in SeeDB2 (Ke et al., 2016), and native fluorescence was ...