She received a cord blood transplant to treat the AML, receiving stem cells carrying a genetic mutation (CCRΔ5/Δ32) which means they lack the CCR5 co-receptor used by HIV to get access to cells ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Impact of nonfunctional chemokine receptor alleles on HIV resistance & disease progression Homozygotes and heterozygotes for CCR5 d32, which are prevalent in European populations, exhibit a strong ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...