In vitro experiments revealed that lack of IL-2 production by CD4+ T cells accounts for the loss of CD25 expression in SLE Treg ... showing a rapid and robust induction of clinical remission in ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Since HRES-1/Rab4 targets CD3ζ and CD4 for lysosomal degradation, we examined this process in NZB/W F1 mice. CD3ζ expression was reduced, while CD4 expression was unchanged in T cells of 4-week-old ...