CD4 + Foxp3 + T regulatory cells (Treg) are required throughout life to maintain a healthy immune system because conventional CD4 + T cells (Tconv) pose a permanent threat of deadly autoimmune attack ...

T cells play a crucial role in the adaptive immune system’s defense against external invasion. To distinguish between self and non-self, T cells use their T cell receptors (TCRs) to recognize ...

The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory ... 2007) to obtain GFP reporter mice for Foxp3. All these mice including non-transgenic ...

Here we have designed a CAR, CD4CAR, which redirects the antigen specificity of CD8+ cytotoxic T cells to CD4-expressing cells. CD4CAR T cells derived from human peripheral blood mononuclear cells ...

The role of CD4+FOXP3+ regulatory T cells (Treg) in human immunodeficiency virus (HIV) infection has been an area of intensive investigation and remains a matter of ardent debate. Investigation and ...