编辑丨王多鱼排版丨水成文抗 PD-1 联合仑伐替尼（lenvatinib，一种多靶点受体酪氨酸激酶抑制剂）治疗在多种肿瘤中均显示出临床疗效，但潜在的免疫学机制尚不清楚。2025 年 1 月 30 ...

TCR can be used to identify naturally tumor-reactive T cells, but little is known about the differences in the TCR repertoires of CD4+ and CD8+ TILs. Methods: TCR high-throughput sequencing was ...

【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议。1月21日，新疆石河子大学研究团队在期刊《Journal of Experimental & ...

While NKT and CD8+ T cells are mainly committed to becoming effector cytotoxic cells, effector CD4+ T helper (Th) cells orchestrate adaptive immune responses through the secretion of cytokines and ...

Figure 1: IFN-γ capture assay enriches tumor-reactive T cells from immunized mice. Figure 3: IFN-γ capture assay detects and enriches tumor-specific T cells from human RCC. In conclusion, the ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

在Nature Cancer期刊以长文的形式发表了题为“ETV7 limits the antiviral and anti-tumor efficacy of CD8+ T cells by diverting their fate towards exhaustion （ETV7通过促进CD8+ T细胞命运向耗竭的转化，限制CD8+ T细胞抗病毒和抗肿瘤的功能）的研究论文 CD8 + ...

We also determined which CD4 + T cell population is critical for induction of negative regulation of CTL tumor immunosurveillance, and found it was dependent on CD1-restricted NKT cells.

ivyGAP data: Infiltrating_Tumor:"SNAP25";"UHRF1" Microvascular_proliferation:"KLF6";"ELTD1" Pseudopalisading ... We apply ELSA to the PBMC data set, which has several different cell types including B ...

Typically, in advancing disease, as the immune system becomes exhausted, it is less able to produce T-cells to defend itself. The CD4/CD8 percentage helps healthcare practitioners see this.