TCR can be used to identify naturally tumor-reactive T cells, but little is known about the differences in the TCR repertoires of CD4+ and CD8+ TILs. Methods: TCR high-throughput sequencing was ...

image: Peripheral blood CD4 + /CD8 + ratios at 12 and 24 weeks may serve as predictive markers for HBsAg clearance in IHCs treated with peg-IFN-α. view more Credit: Shuangsuo Dang, Fengping Wu ...

COUR Pharmaceuticals, a clinical-stage biotechnology company developing first-in-class, disease-modifying therapies designed ...

A study revealed that probiotics combined with chemotherapy and immune checkpoint inhibitors improve survival, gut health, ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

Methods: 12 healthy subjects underwent needle biopsy of knee synovium. Using antibodies directed against CD3, CD4, CD8, L26, Kp-1,and HLA-DR, detailed quantitative immunohistochemical analysis of ...

Institute for Advanced Optics, Hunan Institute of Science and Technology, Yueyang, Hunan 414006, China School of Information Science & Technology, Hunan Institute of Science and Technology, Yueyang, ...

细菌性肺炎是一种严重的公共卫生负担，它不仅导致了大量的发病率和死亡率，还带来了沉重的医疗成本。尽管抗生素和辅助治疗是目前的主要治疗手段，但对于疾病发病机制的深入理解仍然有限。

鳞状细胞癌与基底细胞癌均来自于角质形成细胞的癌变，黑色素瘤来源于黑色素细胞癌变，因此在第一部分内容分析BCC，SCC,黑色素瘤细胞生态图谱后，研究团队将目光聚焦于角质形成细胞以及黑色素细胞。健康角质形成细胞和肿瘤角质形成细胞的二级聚类导致明显分离的健 ...