CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Since the initial development of CRISPR-Cas9, researchers have introduced more precise gene-editing techniques, notably base editing and prime editing. Base editing enables the direct conversion of ...

CRISPR/Cas9 has been widely applied to various plant species accelerating the pace of plant ... The pKSE401 vector was digested by BsaI, then the annealed double strand fragments were ligated into the ...

Advances in CRISPR technologies promise to accelerate the burgeoning pipeline of gene-editing therapies and broaden access to these disease-altering therapies.

sgRNA contains a 20-nucleotide sequence at the 5' end, responsible for determining DNA invader, and a double stranded structure at the 3' side that binds to Cas9. By customizing sgRNA, CRISPR-Cas9 ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Genetic changes are a significant cause of infertility, impacting over 15% of the global population. TLE6, a major protein ...

Crispr Therapeutics gene editing platform is based on the Crispr/Cas9. Cas9 (CRISPR-associated enzyme), which acts as DNA “scissor”, cutting the DNA in a specific region matching a single RNA ...

Its CRISPR/Cas9 is a gene editing technology that allows for precise directed changes to genomic DNA. The company has a portfolio of therapeutic programs across a range of disease areas ...

Many oilseed species have inherent stress-combating mechanisms, including transcription factor regulation. Advances in genome editing tools like CRISPR/Cas9 offer precise genetic modifications, ...