Researchers investigate the sex-dependent microglial response to a colony-stimulating factor 1 receptor (CSF1R) inhibitor.

The study's findings are crucial in the rapidly emerging field of developing disease-modifying therapies that target microglia.

Microglia, the brain’s immune cells, play vital roles in clearing toxins and maintaining neuronal health but can also contribute to neurodegenerative diseases if overactive.

公开资料显示，吡昔替尼(pexidartinib)是一款CSF1R小分子抑制剂，此前已于2019年8月获得美国FDA批准上市，治疗症状性腱鞘巨细胞瘤(TGCT)成人患者。

智通财经APP获悉，1月15日，中国国家药监局药品审评中心(CDE)官网最新公示，第一三共(DSNKY.US)申报的5.1类新药盐酸吡昔替尼胶囊(PLX3397)的上市申请已获得受理。该产品已经于2024年10月被CDE正式纳入优先审评，适用于治疗伴有重度病变或功能受限且无法通过手术改善的症状性腱鞘巨细胞瘤(TGCT)成年患者。公开资料显示，吡昔 ...

B.Sc. Botany, M.Sc. Plant Biology and Biotechnology, Ph.D. Plant Biology and Biotechnology Priyom holds a Ph.D. in Plant Biology and Biotechnology from the University of Madras, India. She is an ...

Journal of Nuclear Medicine January 2025, jnumed.124.268699; DOI: https://doi.org/10.2967/jnumed.124.268699 ...