Unbiased expression profiling, and genetic and pharmacological gain-of-function and loss-of-function approaches were employed to identify molecular signalling in tumour-associated macrophages (TAMs) ...

M1 macrophages are known as classically activated macrophages ... Several chemotaxis inhibitors, such as those targeting CXCR2 and CCR5, are under investigation to hinder the recruitment of ...

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, ...

Dr. Won Jin Ho presented a talk as part of the Immunology Neighborhood Seminar on “Overcoming the tumor immune ...

肝脏巨噬细胞在调节肝细胞代谢和维持肝脏免疫耐受方面发挥核心作用。正常生理条件下，肝脏巨噬细胞倾向于 M2 表型，可通过分泌白细胞介素（IL）-4 和 IL-13 抑制炎症。然而，在 NAFLD 进展时，肝星状细胞激活、血液中脂多糖水平升高以及 FFA 激活炎症小体等变化，会刺激炎症发生，增加分泌促炎细胞因子的 M1 巨噬细胞比例。

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...

中性粒细胞和巨噬细胞是抵御病原体微生物感染的重要免疫细胞。在病原体入侵时，中性粒细胞率先被招募到感染部位，通过吞噬、产生活性氧（ROS）等方式发挥抗菌作用，同时其释放的 NETs 也备受关注。NETs 由双链 DNA、组蛋白和非组蛋白蛋白质组成，在调节免疫反应中发挥重要作用。巨噬细胞则可分化为 M1 和 M2 两种类型，M1 型巨噬细胞分泌促炎细胞因子，增强免疫反应；M2 ...

Objectives The significance of neutrophilic inflammation in obstructive airway disease remains controversial. Recent studies have demonstrated presence of an active neutrophil population in systemic ...