The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...

cAMP critically modulates the development of neuronal connectivity. It is involved in a wide range of cellular processes that require independent regulation. However, our understanding of how this ...

The diagram fully illustrates the regulatory network of CHIP and PDE9A within Purkinje cells, demonstrating the involvement of cGMP and cAMP signaling pathways and their implications for mitophagy and ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.

A new study, "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein" published in Biochemistry, provides key insights into how bacterial cAMP receptor proteins (CRPs) ...

Credit: Dr. Tetsuya Muramoto The study revealed the mechanisms by which periodic intracellular cAMP signal frequencies regulate transcription factor shuttling between the nucleus and cytoplasm and ...

A new study led by Dr. Rodrigo Maillard at Georgetown University, “Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein through Structural Homology,” published in ...

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