Priya Hays, Hays Documentation Specialists, discusses innovations and advancements in the development of personalized cancer ...

CDKN1B 5′UTR mediates its cell cycle-dependent translation and several ... reduces p27–CDK2 inhibition and transforms p27 from inhibitor to substrate of cyclin–CDK2 complexes.

The universal cell-cycle inhibitor p21 Cip1/WAF1 is phosphorylated ... as a mechanism of deregulating cell proliferation in cancer. Figure 1: Oncogene Her2/neu-initiated, Akt-mediated p21 Cip1 ...

retriever generates disease-specific transcriptional drug response signatures by merging transcriptional signatures over time, concentration, and cell-type. These signatures can then be matched to ...

Maintaining treatment with CDK4/6 inhibitors significantly suppresses the growth of breast cancer cells, even after drug resistance has developed, according to new research.

To counteract these challenges, novel strategies aim to restore the cancer immunity cycle. One approach involves directly injecting unadjuvanted influenza vaccines or drug-loaded oncolytic viruses ...

In breast cancer, these proteins can become overactive and cause the cells to grow and divide uncontrollably. CDK4/6 inhibitors interrupt these proteins to slow or even stop the cancer cells from ...

Trilaciclib significantly reduced chemotherapy-induced myelosuppression in extensive-stage small cell lung cancer, which ...

The model, which is predominantly based on genetic gain- or loss-of-function studies, implies that RAS is locked into an active state in cancer and ... phases of the cell cycle, DNA replication ...

The company is developing a CDK2 inhibitor called INX ... with a key role in controlling the cell cycle. They have become an attractive target for new cancer therapies. Patrick Roberts, CEO ...

My laboratory has combined biochemical, molecular, cellular, and genetic approaches to investigate the roles of CDK inhibitors in differentiation ... the genes and and molecular mechanisms by which ...

Whereas dendritic cells are critical for kickstarting the cancer immunity cycle in the lymph node ... one promising strategy will be to use COX inhibitors, such as aspirin—drugs that block ...