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由多糖荚膜包裹的致病菌（encapsulated bacterium, 荚膜细菌）引起的血流感染是导致人类脓毒症和死亡的一个主要原因。医学界早就认识到重症血流感染通常发生在婴幼儿、老年人和免疫力低下的“弱势群体”，而极少发生在健康青壮年个体。这个流行病学现象暗示青壮年个体中存在识别与清除侵袭性细菌的天然免疫力，但目前对这种 “健康免疫力”的机制缺乏认知。