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Hepatitis B (sometimes referred to as hep B) is a liver infection caused by the hepatitis B virus (HBV). It typically causes symptoms like stomach pain, dark urine, fatigue, fever, jaundice (yellowing ...

School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan 523808, P. R. China Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key ...

Autophagy involves the formation of autophagosomes, double-membraned vesicles that engulf damaged organelles, misfolded proteins, and pathogens for degradation in the lysosomes (Levine and Kroemer, ...

When news broke in 2014 that hepatitis C, a viral disease affecting the liver, could be cured thanks to a new class of direct-acting antiviral drugs, many began to wonder how soon it would be before ...

While PSEN1 prefers to bask on the cell surface and sometimes ventures into the early endosomes, PSEN2 contains a sorting sequence that strictly restricts it to late endosomes and lysosomes. As such, ...

Results: The results showed that sesamin significantly accelerated the autophagy flux of L02 cells induced by 9-trans-C18:1 as well as elevated protein levels of transcription factor EB (TFEB) and its ...

抗体偶联药物（Antibody-Drug Conjugate，ADC）是通过连接子将小分子化合物偶联至靶向性抗体或抗体片段上的一类新型的生物技术药物，可以增强药物的靶向性和稳定性，同时减少临床毒副反应、提高治疗指数，且兼具传统小分子药物的杀伤效应和抗体药物的靶向性 ...