引言在我们的身体中，免疫系统宛如一支无形的“卫士”，时刻守护着健康的堡垒。然而，这支强大的“军队”如何在复杂的组织环境中迅速适应、精准定位并有效发挥作用，仍是科学界的核心难题之一。近年来，研究人员逐渐发现，组织驻留记忆CD8 ...

【导读】结直肠癌（CRC）通常会营造出免疫抑制的微环境，从而阻碍免疫治疗的响应。有效的治疗方案仍难以寻觅。1月22日，南京中医药大学/南京大学/安徽医科大学研究人员合作共同在期刊《Advanced ...

【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议。1月21日，新疆石河子大学研究团队在期刊《Journal of Experimental & ...

The extracellular domain of human NKG2D was synthesized (Genewiz) and fused to a CAR backbone comprising a human CD8a hinge spacer and transmembrane domain, 4-1BB costimulatory domain, and CD3ζ. The ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

Cell samples prepared as described above were pre-treated with anti-CD16/CD32 (clone: 2.4G2) FcR blocker for 15 minutes on ice and then stained for surface antigens with the following combinations of ...

Melanoma Among Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study Adults with stage IB-IIIA (American Joint Committee on Cancer seventh edition) resectable NSCLC ...

This important work advances our understanding of trained immunity, especially in the context of Bacillus Calmette-Guérin (BCG) administration and host-pathogen interactions. The evidence supporting ...

新华社香港1月8日电（记者王子江）参加2025年哈尔滨亚冬会的中国香港代表团8日宣布成立，代表团由113人组成，其中运动员76人，创下中国香港队参加亚冬会的历史纪录。 中国香港奥委会当天在奥运大楼举行代表团授旗仪式，香港特区政府文化体育及旅游局局长 ...

6 Azrieli Faculty of Medicine of Bar-Ilan University, Safed, Israel Correspondence to Dr Chaim Putterman, Azrieli Faculty of Medicine, Bar-Ilan University, Zefat, Israel; ...