The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

Extended cash runway into late 2027, beyond a potentially registration-enabling azenosertib data readout from DENALI Part 2Planned workforce ...

The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer. Aa Aa Aa Eukaryotic genomes are ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. Natural killer (NK) cells are pivotal in the innate immune response ...

Researchers identify distinct molecular and immune profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma.

This exhaustion is influenced by immune checkpoint receptors, which are inhibitory cell surface receptors that can suppress antitumor immunity. Notably, intracellular checkpoint molecules within ...

Checkpoint activation results in the stabilization of stalled forks, prevents further origin firing, and creates a cellular milieu that promotes the resolution of replication fork blocks before entry ...