We offer a comprehensive suite of immune checkpoint-related products, including high-quality proteins, inhibitor screening ...

Small molecule chemical compounds block the function of major immune checkpoint molecules by (I) competitively binding with immune checkpoint molecules to block their combination with paired ...

Notably, intracellular checkpoint molecules within NK cells, such as FBP-1, EZH2, CIS, TIPE2, and HIF-1α, play a significant role in NK cell exhaustion by affecting their metabolism ...

The difficulty in targeting immune checkpoint proteins is their flat and dynamic surfaces, which don't bind small molecules easily. To address this issue, Gabr and Abdel-Rahman looked to the co ...