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中药及其活性成分抗黑色素瘤转移的研究进展
EMT 的一个标志性特征是上皮细胞完整性丢失,这是由维持上皮细胞间接触的黏附蛋白(如E-cadherin )降解造成的[56-57] 。这种降解的一个主要驱动因素是基质金属蛋白酶(matrix metalloproteinase ,MMP )进行蛋白水解消化,因此,MMP 家族蛋白与EMT 过程联系非常紧密[58 ...
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