Ciprofloxacin 400 mg twice daily IV will achieve the recommended PK-PD goal (AUC 0–24 /MIC ratio >125) in most patients on CVVHDF. Concomitant hepatic and renal impairment results in a prolonged ...
Background: The study aimed to investigate the pharmacokinetics of intravenous ciprofloxacin and the adequacy of 400 mg every 12 hours in critically ill Intensive Care Unit (ICU) patients on ...