One is that the DNA template somehow becomes defective during replication, and causes the polymerase to pause (Figures 3 and 4a). For example, a DNA base can be chemically modified or ...

One example of uneven coverage is the chapter ... the replication of medically important DNA viruses. As for cellular DNA replication, significant advances in our understanding of how these ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

The two DNA polymerases at the replication fork do not communicate at all. Their behavior is completely independent and stochastic. They each sample from the same distribution of possible ...

DNA replication is happening continuously throughout ... but also for the development of new medicines for many diseases." For example, in cancer -- marked by rapidly dividing cells -- a medicine ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous ... One strand is sequestrated ...

The reliability of the DNA replication process depends on genome ... as there are many ways to produce these variations," Yang said. For example, lung cancer is frequently driven by tobacco ...

These analogs can interfere with DNA replication and induce cell death in rapidly dividing cancer cells or inhibit viral replication. Examples include: 5-Fluorouracil (5-FU): A pyrimidine analog used ...