After administration of the DNA, antigens are produced and stimulate an immune response. Mathot et al. assess stability of an adenovirus-based vaccine vector lyophilized and stored long-term.

Immunizing the host with a piece of viral DNA rather than an antigenic protein fragment of the virus, helps to stimulate the generation of cell-mediated immunity (Fig. 2). DNA vaccines contain the ...

There is no doubt that reverse genetics and reverse vaccinology are important directions for future development, and nucleic acid vaccines such as DNA vaccines, live vector vaccines, and mRNA vaccines ...

Each of these personal evaluations provides us with new drug targets to be used in combination with DNA cancer vaccines which can have additive or even synergistic effects. Discovering the markers ...

GSK is prioritizing development of its hepatitis B treatment bepirovirsen as the pharma ends work on another potential ...

There are many potential problems and unanswered questions concerning the use of DNA vaccines. [14] The possibility of insertional mutagenesis is a concern that needs to be more rigorously tested.

24, 2025 — A therapeutic vaccine targeting human papillomavirus type 16 (HPV16) induced regression in high-grade precancerous cervical lesions, according to the results from a phase II clinical ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.