This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

This developmental plasticity requires a strict temporal and spatial control of the cell cycle. Cell-cycle activation in quiescent cells is correlated with a change in chromatin structure and ...

Cell cycle exit is when cells stop dividing and enter a quiescent state, also named G0. Cells exit the cell cycle in response to nutrient- or growth factor deprivation or in response to signals ...

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The cell cycle was analyzed using a cell cycle detection kit (MultiSciences ... following the manufacturer’s instructions. Nuclei were stained with DAPI. In the dual immunofluorescence staining ...

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research ...

The TMA was stained for HE and other specific biomarkers, such as BAP31, E-cadherins, N-cadherins, vimentin, and 4,6-diamidino-2-phenylindole (DAPI). Each sample was accompanied by clinical data, ...

Jan. 23, 2025 — Researchers have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some ...

Single-cell RNAseq analysis in human and murine lungs suggests the presence of two HIGD1B+ pericyte subtypes. Upon hypoxia, type 1 pericytes remain quiescent in the capillary network, while type 2 PCs ...

Hubei Key Laboratory of Genetic Regulation & Integrative Biology, Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, School of Life Sciences, Central China Normal University, ...

The cycle of abuse includes four stages—tension building, abuse, reconciliation, and calm—that allow abusers to control their victims through fear and manipulation. This pattern can trap victims and ...