Dexamethasone provided 4 mg at every 6 hours, the usual initial dose—equivalent to 400 mg of cortisol per day—is about 20 times the normal rate of endogenous production. In patients who have ...

The usual but empirical initial dose in brain tumor patients is an intravenous bolus of 10 mg of dexamethasone, followed by a maintenance dose of 4 mg given by the intravenous (IV) route every 6 ...