In traditional directed evolution approaches ... or when more than one property is being selected for. “We need the enzyme to be highly active, stable in the process, and tolerant of high ...

A new ML-guided platform can design thousands of new enzymes, predict how they will behave in the real world, and test their ...

Researchers from the Manchester Institute of Biotechnology and the Department of Chemistry at The University of Manchester ...

Enzymes are crucial to life. They are nature's little catalysts. In the gut, they help us digest food. They can enhance ...

This highly intense and ambitious course teaches molecular evolutionary methods and principles of biological chemistry. Several teams of two students create and characterize individual enzyme variants ...

Using techniques like directed evolution, we can engineer enzymes to optimize them towards our desired activities by mimicking the natural selection process in the laboratory. To this end we are ...

RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...