Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

These platforms enable the generation of new, more relevant therapeutics against fibrosis and solid tumors, and meaningful biomarkers to ensure their delivery to the right patients. The ECM ...

Lipid peroxidation products are emerging as important stimuli to ECM production ... efforts to use antioxidants as therapy for hepatic fibrosis (see section on Therapy of Hepatic Fibrosis ...

Importantly, fibrosis is not a static process; it is reversible under certain conditions, as inflammatory responses subside ...

Organoids contain multiple organ-specific cell types interacting with each other and ECM proteins, thereby mimicking the functionality and structure of organs in vivo. This allows researchers to model ...

The results revealed that fibroblast-like cells predominantly drove fibrosis and scar formation in post-treatment tissue, gradually fanning out over the region where the tumor used to be and secreting ...